Researcher firas khatib tells rachel martin, host of weekends on all things. Media in category firas al khatib the following 5 files are in this category, out of 5 total. Crystal structure of a monomeric retroviral protease solved by protein folding game players. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction ta. Researchers created the game foldit to simulate protein folding and used teams of online gamers to help solve the structure of an enzyme. Select the foldit standalone download link for your platform. According to firas khatib, a researcher at the university of washingtons. Foldit players interact with protein structures using direct manipulation tools and userfriendly versions of algorithms from the. Foldit game engages the public in research uw college of. Crystal structure of a monomeric retroviral protease. For specific hard problems, foldit player solutions can in some cases outperform stateoftheart computational methods. Oct 31, 2009 the university of washington are investigating whether the brainpower of humans worldwide can be. Thesis university of illinois at urbanachampaign elkhatib, f.
Insiders say todd phillips never pitched origin film series on other dc characters. Patents, intellectual property, and provisional disclosures. Online gamers help solve protein structure scientific. Foldit standalone is available for download at, under the rosetta license, which is. Firas khatib, ambroise desfosses, foldit players, brian koepnick, jeff flatten, zoran popovic, david baker, seth cooper, irina gutsche, scott horowitz. View firas khatib s profile on linkedin, the worlds largest professional community. Join facebook to connect with firas al khatib and others you may know. Returning veteran firas al khatib, an exfavourite of shanghai shenhua, could hold key for syria against australia in tuesdays world cup playoff. Foldit is a multiplayer online game in which players collaborate and compete to create accurate protein structure. Returning veteran firas alkhatib, an exfavourite of shanghai shenhua, could hold key for syria against australia in tuesdays world cup playoff.
Darpa, nsf, nih, hhmi, microsoft, adobe, and rosettacommons this material is based upon work supported by the national science foundation under grant no. It looks like we dont have any biography for firas al khatib yet be the first to contribute. Now close to 200,000 registered players around the world are playing foldit. Seth cooper, firas khatib, ilya makedon, hao lu, janos barbero, david baker, james fogarty, zoran popovic and foldit players. Foldit playerss research works carnegie mellon university, pa. Curriculum vitae general information boston university. Join facebook to connect with firas khatib and others you may know. It is part of an experimental research project developed by the university of washington, center for game science, in collaboration with the uw department of biochemistry. Science editors choice highresolution structure of a retroviral protease folded as a monomer. Sep 19, 2011 this is one small piece of the puzzle in being able to help with aids, firas khatib, a biochemist at the university of washington, the institution which invented the game, told msnbc. Solving puzzles for science life sciences research weekend 2010. The improvement in k m but lack of change in k cat are consistent with the design model and crystal structure. In contrast to most commandline or batch interactions with rosetta, foldit standalone is designed to allow easy, realtime, direct manipulation of protein structures, while also giving access to the extensive power of rosetta computations.
Pdf algorithm discovery by protein folding game players. Online gamers help solve mystery of critical aids virus. Nov 22, 2011 foldit is a multiplayer online game in which players collaborate and compete to create accurate protein structure models. However, very little is known about how collaborative gameplay produces these results and whether foldit player strategies can be formalized and. Also, a protein can fold up into so many possible shapes that a. Online gamers help solve protein structure scientific american. Pdf wefold paper final rodrigo faccioli, silvia crivelli. Algorithm discovery by protein folding game players. When scientists fail, call in the gamers for more than a decade, researchers were stumped by the structure of a tiny protein that causes aids in. Seth cooper, adrien treuille, janos barbero, andrew leaverfay, kathleen tuite, firas khatib, alex cho snyder, michael beenen, david salesin, david baker, zoran popovic, the challenge of designing scientific discovery games, proceedings of the fifth international conference on the foundations of digital games, p. Foldit players were able to sample closer to the native fold by rebuilding several incorrect loops fig. Foldit standalone is an interactive graphical interface to the rosetta molecular modeling package. Robert kleffner, jeff flatten, andrew leaverfay, david baker, justin b.
Citation if you use foldit standalone in your work, please cite. Crystal structure of a monomeric retroviral protease solved. Fold xx is a new fold, previously unobserved in natural proteins. Proceedings of the national academy of sciences of the united states of america 2011. Firas elkhatib, phd, gives us a short introduction to himself and then explains some of his work developing the bionic pancreas focusing especially on the challenges of developing an algorithm. Online gamers help solve mystery of critical aids virus enzyme. Just click the edit page button at the bottom of the page or learn more in the biography submission guide. Algorithm discovery by protein folding game players pnas. Khatib lab department of computer and information science university of massachusetts dartmouth. Get season stats, career statistics, game logs and injury updates on the syria none. Oct 02, 2011 when scientists fail, call in the gamers for more than a decade, researchers were stumped by the structure of a tiny protein that causes aids in rhesus monkeys.
Oct 08, 2011 online gamers help solve mystery of critical aids virus enzyme. Following the failure of a wide range of attempts to solve the crystal structure of mpmv retroviral protease by molecular replacement, we challenged players of the protein folding game foldit to. Foldit playerss 9 research works with 229 citations and 1521 reads, including. It is implemented in crossplatform cand binary executables are available for windows, macos and linux. Foldit is an online puzzle video game about protein folding. Siegel7,8,9, firas khatib10 and seth cooper1, 1college of computer and information science, northeastern university, boston, ma 02115, usa, 2department of. The university of washington are investigating whether the brainpower of humans. Online gamers solve 10yearold science problem in 10 days. F khatib, f dimaio, s cooper, m kazmierczyk, m gilski, s krzywda. Pdf crystal structure of a monomeric retroviral protease. The michaelis constants, k mdiene and k mdienophile table 1, of ce6 are improved 6 fold and 3 fold respectively compared to the starting design, but the turnover number k cat is unchanged. Analysis of social gameplay macros in the foldit cookbook.
He is syrias alltime record goalscorer with 36 goals. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the national science foundation. View firas khatibs profile on linkedin, the worlds largest professional community. Media in category firas alkhatib the following 5 files are in this category, out of 5 total. Tyka, kefan xu, ilya makedon, zoran popovic, david baker and foldit players. The protein structure prediction problem continues to elude scientists. See the complete profile on linkedin and discover firas. Saudi arabian group, leading building materials and investment group headquartered in khobar ksa. The university of washington are investigating whether the brainpower of humans worldwide can be. This is one small piece of the puzzle in being able to help with aids, firas khatib, a biochemist at the university of washington, the institution which invented the game, told msnbc.